Cinnamic acids and derivatives
Apexbio Technology LLC Tyrphostin AG 1296 146535-11-7 10mM (in 1mL DMSO)
Tyrphostin AG 1296 (CAS 146535-11-7) is a selective inhibitor of platelet-derived growth factor receptor (PDGFR) kinase via ATP-competitive binding Its inhibitory activity (IC50 0 3 0 5 M) results from inducing conformational changes in the ATP-binding domain of PDGFR blocking receptor autophosphorylation induced by ligand binding In vitro studies demonstrate inhibition of PDGF-stimulated mitogenesis (IC50 1 5 M) and cell proliferation (IC50 3 2 M) using Swiss 3T3 cells without significant effects on EGF receptor signaling at concentrations up to 100 M Tyrphostin AG 1296 serves as a research tool for investigating PDGFR-mediated signaling pathways
Apexbio Technology LLC BIBF 1202 894783-71-2 10mg
BIBF 1202 (CAS 894783-71-2) is a carboxylate metabolite derivative of BIBF 1120 characterized as a selective inhibitor of vascular endothelial growth factor receptor 2 (VEGFR2) kinase In biochemical assays BIBF 1202 demonstrates inhibitory activity against VEGFR2 kinase with an IC50 of 62 nM This compound is frequently employed in studies investigating the regulation of the VEGFR2 signaling pathway and its role in endothelial cell function Additionally BIBF 1202 is utilized in preclinical models related to tumor angiogenesis and associated pharmacological research
Apexbio Technology LLC Entacapone sodium salt 1047659-02-8 100mg
Entacapone sodium salt (CAS 1047659-02-8) is a nitrocatechol small molecule that acts as a selective and reversible inhibitor of catechol-O-methyltransferase (COMT) a Mg2 -dependent enzyme involved in the metabolism of catecholamines and related compounds In biochemical assays entacapone exhibits an IC50 of 20 1 nM and a Ki of 10 7 nM for COMT inhibition The presence of a nitro group ortho to the hydroxyl group in its structure contributes to its inhibitory potency Entacapone has been widely used in research focused on Parkinson s disease particularly to study the modulation of levodopa bioavailability and pharmacokinetics
Apexbio Technology LLC Cinnamic acid 621-82-9 100mg
Cinnamic acid (CAS 621-82-9) is an aromatic unsaturated carboxylic acid naturally occurring in various plants particularly in cinnamon and vanilla It exhibits a range of bioactivities including antimicrobial anti-inflammatory and antioxidant effects Mechanistically cinnamic acid has been shown to modulate inflammatory pathways and oxidative stress responses thereby influencing cellular signaling cascades associated with disease progression Owing to these properties it is investigated in biomedical research for its potential in cancer intervention as well as for broader applications in pharmacological studies of inflammation and infection
Matrix Scientific 4-CHLOROCINNAMIC ACID-25G
4-Chlorocinnamic acid, 99%; 25g,C9H7ClO2, MFCD00004396, mw 182.61, [1615-02-7]
Matrix Scientific 4-FLUOROCINNAMIC ACID-25G
4-Fluorocinnamic acid, 98%; 25g,C9H7FO2, MFCD00004395, mw 166.15, [459-32-5]
Selleck Chemical LLC AG 494
AG-494 a member of the tyrphostin family of tyrosine kinase inhibitors is a potent inhibitor of EGF receptor autophosphorylation (IC50 1 2 M) and EGF-dependent cell growth (IC50 6 M)
Apexbio Technology LLC CURCUMIN 100MG
Curcumin (CAS 458-37-7) is a natural small molecule known to inhibit tyrosinase activity with an IC50 of 47 M It modulates multiple signaling pathways involved in tumorigenesis and inflammation influencing transcription factors growth factors cytokines receptors and enzymes Clinical trials at Phase I reported no observed toxicity at doses up to 12 g/day however oral bioavailability is limited ( 1% in Phase I/II studies) Additionally curcumin demonstrates potential for Alzheimer s research as evidenced by reducing beta-amyloid (A 40 A 42) production via downregulating presenilin-1 and GSK-3 in SH-SY5Y neuroblastoma cells
Selleck Chemical LLC Tyrphostin AG 1296
Tyrphostin AG 1296 is an inhibitor of PDGFR with IC50 of 0 3-0 5 M no activity to EGFR Tyrphostin AG1296 inhibits FGFR and c-Kit with IC50 of 12 3 M and 1 8 M in Swiss 3T3 cells Tyrphostin AG1296 induces dramatic apoptosis in A375R cells
Selleck Chemical LLC 3-Hydroxycinnamic acid
3-hydroxycinnamic acid (meta-Coumaric acid m-Coumaric acid m-Coumarate) is an aromatic acid that can be found in vinegar
Selleck Chemical LLC Curcumin analog C1
Curcumin analog C1 (Curcumin analog Compound C1) is a potent transcription factor EB (TFEB) activator with promise for the prevention or treatment of Alzheimer s disease
Selleck Chemical LLC 2-Methoxycinnamic acid
2-Methoxycinnamic acid (AI3-11206) is a cinnamic acid with magnetic properties
Sigma Aldrich Fine Chemicals Biosciences Curcumin from Curcuma longa (Turmeric), powder | 458-37-7 | MFCD00008365 | 10g
Curcumin from Curcuma longa (Turmeric), powder | Purity: 65% | 368.38 | 458-37-7 | MFCD00008365 | 10g
Sigma Aldrich Fine Chemicals Biosciences alpha-Cyano-4-hydroxycinnamic acid >=98% (TLC), powder | 28166-41-8 | MFCD00004204 | 25G
alpha-Cyano-4-hydroxycinnamic acid >=98% (TLC), powder | Purity: >=98% (TLC) | Mol Wt: 189.17 | 28166-41-8 | MFCD00004204 | 25G
eMolecules 2-(4'-Fluorobenzyloxy)phenylboronic acid | 870779-01-4 | 1G | Purity: 98%
Combi-Blocks | 2-(4'-Fluorobenzyloxy)phenylboronic acid | 1G | 870779-01-4 | MFCD07369749
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